文献类型：期刊文献

英文题名：Antioxidant activity of compounds from the medicinal herb Aster tataricus

作者：Ng, TB; Liu, F; Lu, YH; Cheng, CHK; Wang, ZT

机构：[1]Chinese Univ Hong Kong, Fac Med, Dept Biochem, Shatin, Hong Kong, Peoples R China;[2]Nankai Univ, Dept Microbiol, Tianjin 300071, Peoples R China;[3]E China Univ Sci & Technol, Inst Biochem, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai, Peoples R China

年份：2003

卷号：136

期号：2

起止页码：109

外文期刊名：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000186102200002)】；

语种：英文

外文关键词：antioxidant; medicinal herb; Aster tataricus; shionone; epifriedelinol; quercetin; kaempferol; scopoletin; emodin; aurantiamide acetate; 1,7-dihydroxy-6-methyl-anthraquinone

摘要：A number of compounds were isolated from the medicinal plant Aster tataricus including shionone, epifriedelinol, quercetin, kaempferol, scopoletin, emodin, aurantiamide acetate and 1,7-dihydroxy-6-methyl-anthraquinone. The compounds were compared with regard to their ability in inhibiting hemolysis of rat erythrocytes induced by 2'-2' azobis (2-amidinopropane) dihydrochloride, lipid peroxidation using the FeSO4-ascorbic acid system, and generation of superoxide radicals using a phenazine methosulfate-nicotinamide adenine dinucleotide system. The effects on the Fe-bleomycin-induced DNA damage reflected pro-oxidant activity. Quercetin and kaempferol were most potent in inhibiting hemolysis, lipid peroxidation and superoxide radical generation. Scopoletin and emodin were similar to quercetin and kaempferol in inhibiting superoxide radical generation and second to them in inhibiting lipid peroxidation. Aurantiamide acetate exhibited some inhibitory activity toward superoxide radical generation. 1,7-dihydroxy-6-methyl-anthraquinone exerted an inhibitory activity only on superoxide radical generation. Shionone and epifriedelinol did not display any antioxidant activity. Quercetin and kaempferol, but not the remaining compounds, exhibited some pro-oxidant activity. (C) 2003 Elsevier Inc. All rights reserved.