文献类型：期刊文献

英文题名：Intrinsic Apyrase-Like Activity of Cerium-Based Metal-Organic Frameworks (MOFs): Dephosphorylation of Adenosine Tri- and Diphosphate

作者：Yang, Jian[1];Li, Ke[1];Li, Chunzhong[1];Gu, Jinlou[1]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：59

期号：51

起止页码：22952

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20223412618105);WOS:【SCI-EXPANDED(收录号:WOS:000580516800001)】；

基金：This work was financially supported by the Natural Science Foundation of China (21975072, 51902106, 21838003), the Natural Science Foundation of Shanghai (18ZR1408700).

语种：英文

外文关键词：adenosine triphosphate; apyrase; biomimetic chemistry; high-energy phosphate bonds; metal-organic frameworks (MOFs)

摘要：Apyrase is an important family of extracellular enzymes that catalyse the hydrolysis of high-energy phosphate bonds (HEPBs) in ATP and ADP, thereby modulating many physiological processes and driving life activities. Herein, we report an unexpected discovery that cerium-based metal-organic frameworks (Ce-MOFs) of UiO-66(Ce) have intrinsic apyrase-like activity for ATP/ADP-related physiological processes. The abundant Ce-III/Ce(IV)couple sites of Ce-MOFs endow them with the ability to selectively catalyse the hydrolysis of HEPBs of ATP and ADP under physiological conditions. Compared to natural enzymes, they could resist extreme pH and temperature, and present a broad range of working conditions. Based on this finding, a significant inhibitory effect on ADP-induced platelet aggregation was observed upon exposing the platelet-rich plasma (PRP) to the biomimetic UiO-66(Ce) films, prefiguring their wide application potentials in medicine and biotechnology.