文献类型：期刊文献

英文题名：Synthesis of Sterically Protected Xanthene Dyes with Bulky Groups at C-3′ and C-7′

作者：Lei, Zuhai[2];Li, Xinran[2];Li, Yi[2];Luo, Xiao[2];Zhou, Miaomiao[2];Yang, Youjun[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Pharm, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：80

期号：22

起止页码：11538

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20154801620672);WOS:【SCI-EXPANDED(收录号:WOS:000365462600034)，CCR-EXPANDED(收录号:WOS:000365462600034)】；

基金：The work is supported by the Shanghai Rising-Star Program (No. 13QA1401200) and the National Natural Science Foundation of China (Nos. 21372080 and 21572061).

语种：英文

外文关键词：Scaffolds

摘要：Substitution of-the xanthene scaffold,with-bulky groups at C-3' and C-7' is expected to protect the electrophilic central methine, carbon against nucleophilic attack. and inhibit, stacking. However, such,structures are not readily prepared via traditional xanthene syntheses. We have devised an alternative and :convenient synthesis to enable facile preparation of this subset of xanthene dyes Under mild conditions and in good yields.