文献类型：期刊文献

英文题名：Preparation of α-Chloroketones via Oxo/Chloro Difunctionalization of Unactivated Alkenes under Mild Conditions

作者：Zhu, Xuheng[1,2];Li, Chaolin[3];Yang, Xianjin[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Sichuan Police Coll, Luzhou 64600, Sichuan, Peoples R China

年份：2026

卷号：91

期号：7

起止页码：2749

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20260820146575);WOS:【SCI-EXPANDED(收录号:WOS:001681303100001)】；

基金：This study was financially supported by the Suzhou Modear Technology Co., Ltd., the National Natural Science Foundation of China (21372077), and the State Key Laboratory of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources (WFKF2017-04).

语种：英文

外文关键词：Drug products - Medicinal chemistry

摘要：A one-step synthesis of alpha-chloroketones via transition metal-free-mediated oxo/chloro difunctionalization of unactivated alkenes using N-chloro-N-fluorobenzenesulfonamide (CFBSA) is reported, and both aromatic and aliphatic alkenes can be efficiently converted into their corresponding alpha-chloroketones by simply choosing different conditions. This reaction system has several characteristics such as a wide substrate scope, excellent functional group tolerance, mild conditions, low cost, and good yield stability in scale-up reactions, broadening the methodology for the late-stage modification of drugs and natural products.