文献类型：期刊文献

英文题名：A Manganese-Based Metal-Organic Framework as a Cold-Adapted Nanozyme

作者：Chen, Yao[1];Tian, Qing[1];Wang, Haoyu[1];Ma, Ruonan[2];Han, Ruiting[1];Wang, Yu[1];Ge, Huibin[1];Ren, Yujing[1];Yang, Rong[1];Yang, Huimin[3];Chen, Yinjuan[4,5];Duan, Xuezhi[6];Zhang, Lianbing[1];Gao, Jie[1];Gao, Lizeng[2];Yan, Xiyun[2];Qin, Yong[1,3]

机构：[1]Northwestern Polytech Univ, Sch Life Sci, 127 Youyi Rd, Xian 710072, Peoples R China;[2]Chinese Acad Sci, Inst Biophys, CAS Engn Lab Nanozyme, 15 Datun Rd, Beijing 100101, Peoples R China;[3]Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, 27 Taoyuan Rd, Taiyuan 030001, Peoples R China;[4]Changzhou Univ, Innovat Ctr, Adv Catalysis & Green Mfg Collaborat, 21 Yinghu Rd, Changzhou 213164, Peoples R China;[5]China Univ Petr East China, State Key Lab Heavy Oil Proc, 66 West Changjiang Rd, Qingdao 266580, Peoples R China;[6]East China Univ Sci & Technol, State Key Lab Chem Engn, 500 Dongchuan Rd, Shanghai 200237, Peoples R China

年份：2024

卷号：36

期号：10

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20224713133738);WOS:【SCI-EXPANDED(收录号:WOS:000882952200001)】；

基金：Y.C. and Q.T. contributed equally to this work. This work was financially supported by the following funding: National Natural Science Foundation of China (22102130 and 31971315); National Natural Science Foundation of China Innovative Research Group (22121003); Science and Technology Committee of the Central Military Commission (19-163-12-ZD030-001-01). The authors would like to thank the Analytical & Testing Center of Northwestern Polytechnical University for Electron Microscopy, XPS and XRD.

语种：英文

外文关键词：antiviral effect; cold-adapted enzymes; cryogenic therapy; metal-organic frameworks; nanozymes

摘要：The development of cold-adapted enzymes with high efficiency and good stability is an advanced strategy to overcome the limitations of catalytic medicine in low and cryogenic temperatures. In this work, inspired by natural enzymes, a novel cold-adapted nanozyme based on a manganese-based nanosized metal-organic framework (nMnBTC) is designed and synthesized. The nMnBTC as an oxidase mimetic not only exhibits excellent activity at 0 degrees C, but also presents almost no observable activity loss as the temperature is increased to 45 degrees C. This breaks the traditional recognition that enzymes show maximum activity only under specific psychrophilic or thermophilic condition. The superior performance of nMnBTC as a cold-adapted nanozyme can be attributed to its high-catalytic efficiency at low temperature, good substrate affinity, and flexible conformation. Based on the robust performance of nMnBTC, a low-temperature antiviral strategy is developed to inactivate influenza virus H1N1 even at -20 degrees C. These results not only provide an important guide for the rational design of highly efficient artificial cold-adapted enzymes, but also pave a novel way for biomedical application in cryogenic fields.