文献类型：期刊文献

英文题名：Thermodynamic analysis of the solubility of polymorphic cytarabine in a variety of pure solvents

作者：Yang, Jinsuo[1];Qian, Gang[1];Wu, Yanyang[2];Zhang, Xiangyang[1];Liu, Yang[3];Li, Zhenwu[3];Zhou, Xinggui[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Chem Engn Res Ctr, Shanghai 200237, Peoples R China;[3]Hisun Co Ltd, Taizhou, Peoples R China

年份：2017

卷号：445

起止页码：1

外文期刊名：FLUID PHASE EQUILIBRIA

收录：;EI(收录号：20171903647936);WOS:【SCI-EXPANDED(收录号:WOS:000403516700001)】；

基金：We thank the financial support by the National Natural Science Foundation of China (NSFC, No. 21406071), the Fundamental Research Funds for the Central Universities (No. 22A201514006), the Open Project of State Key Laboratory of Chemical Engineering (SKL-ChE-16C03), Shanghai Pujiang Program (No. 16PJD019), and Hisun Co. Ltd..

语种：英文

外文关键词：Cytarabine; Solubility; Solvent; Thermodynamic analysis

摘要：A systematic measurement of the solubility of cytarabine in water, methanol, ethanol, and ethanediol at atmospheric pressure has been carried out at temperature ranging from (293.15-333.15) K by a gravimetric method. The melting temperature, T-m, and molar fusion enthalpy, Delta H-f, of cytarabine were measured using DSC. The results showed that the dissolution of cytarabine in all examined solvents is endothermic process. Subsequently, the experimental data were well correlated using modified Apelblat equation, lambda h equation, Wilson model, and NRTL model, respectively. Further, combining the measured solubility data and calculated ideal solubility data, activity coefficients of cytarabine in different solvents were estimated by neglecting the validity of heat capacity, which were then fitted to a van't Hoff like equation to estimate the mixing enthalpy, Delta H-mix, and mixing entropy, Delta S-mix, respectively. Moreover, polymorphic behavior of cytarabine has been observed, which was validated using DSC and PXRD analysis. (C) 2017 Elsevier B.V. All rights reserved.