文献类型：期刊文献

英文题名：Fluorinated-functionalized hyaluronic acid nanoparticles for enhanced photodynamic therapy of ocular choroidal melanoma by ameliorating hypoxia

作者：Li, Jipeng[1];Xue, Yudong[2];Tian, Jun[2];Liu, Zeyang[1];Zhuang, Ai[1];Gu, Ping[1];Zhou, Huifang[1];Zhang, Weian[2];Fan, Xianqun[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai Peoples Hosp 9,Dept Ophthalmol, Shanghai 200011, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：237

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20201008269911);WOS:【SCI-EXPANDED(收录号:WOS:000522387000019)】；

基金：This work was supported by the National Key Research and Development Plan (2018YFC1106100), the National Natural Science Foundation of China (81770960, 81600766, 21574039 and 51173044), the project was also funded by The Science and Technology Commission of Shanghai (17DZ2260100), Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (20152228), the Ph.D. Innovation Fund of Shanghai Jiao Tong University School of Medicine (BXJ201933, BXJ201929). All animal experiments were approved by the Animal Research Committee of Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine.

语种：英文

外文关键词：Photodynamic therapy; Fluorinated-functionalized hyaluronic acid; Hypoxia; Oxygen carrier

摘要：Photodynamic therapy (PDT) is a method for killing cancer cells by employing reactive singlet oxygen (O-1(2)). However, the inherent hypoxia and oxygen consumption in tumors during PDT lead to a deficient oxygen supply, which in turn hinder the photodynamic efficacy. To overcome this issue, fluorinated-functionalized polysaccharide-based nanocomplexes were prepared by anchoring perfluorocarbons (PFCs) and pyropheophorbide a (Ppa) onto the polymer chains of hyaluronic acid (HA) to deliver O-2 in hypoxia area. These amphiphilic conjugates can self-assemble into micelles and its application in PDT is evaluated. Due to the high oxygen affinity of perfluorocarbon segments, and the tumor-targeting nature of HA, the photodynamic effect of the oxygen selfcarrying micelles is remarkably enhanced, which is confirmed by increased generation of O-1(2) and elevated phototoxicity in vitro and in vivo. These results emphasize the promising potential of polysaccharide-based nanocomplexes for enhanced PDT of Ocular Choroidal Melanoma.