文献类型：期刊文献

英文题名：Cellular Internalization of Rod-Like Nanoparticles with Various Surface Patterns: Novel Entry Pathway and Controllable Uptake Capacity

作者：Xue, Jiaxiao[1];Guan, Zhou[1];Lin, Jiaping[1];Cai, Chunhua[1];Zhang, Wenjie[2];Jiang, Xinquan[2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat,Minist Educ, State Key Lab Bioreactor Engn,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Hosp 9, Sch Med, Dept Prosthodont, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

年份：2017

卷号：13

期号：24

外文期刊名：SMALL

收录：;EI(收录号：20171803637021);WOS:【SCI-EXPANDED(收录号:WOS:000403805900003)】；

基金：J.X. and Z.G. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (21234002, 21474029, 51303055, and 51573049) and the National Key Research and Development Program of China (2016YFC1102900). Support from Project of Shanghai Municipality (15QA1401400, 15ZZ028, and 14DZ2261205) is also appreciated.

语种：英文

外文关键词：Polyethylene glycols - Molecular dynamics - Molecular biology - Block copolymers - Polyethylene oxides - Self assembly - Targeted drug delivery - Controlled drug delivery

摘要：The cellular internalization of rod-like nanoparticles (NPs) is investigated in a combined experimental and simulation study. These rod-like nanoparticles with smooth, abacus-like (i.e., beads-on-wires), and helical surface patterns are prepared by the cooperative self-assembly of poly(gamma-benzyl-l-glutamate)-block-poly(ethylene glycol) (PBLG-b-PEG) block copolymers and PBLG homopolymers. All three types of NPs can be internalized via endocytosis. Helical NPs exhibit the best endocytic efficacy, followed by smooth NPs and abacus-like NPs. Coarse-grained molecular dynamics simulations are used to examine the endocytic efficiency of these NPs. The NPs with helical and abacus-like surfaces can be endocytosed via novel "standing up" (tip entry) and "gyroscope-like" (precession) pathways, respectively, which are distinct from the pathway of traditional NPs with smooth surfaces. This finding indicates that the cellular internalization capacity and pathways can be regulated by introducing stripe patterns (helical and abacus-like) onto the surface of rod-like NPs. The results of this study may lead to novel applications of biomaterials, such as advanced drug delivery systems.