文献类型：期刊文献

英文题名：Extensive in vitro activity of guanidine hydrochloride polymer analogs against antibiotics-resistant clinically isolated strains

作者：Zhou, Zhongxin[1,3]; Wei, Dafu[2]; Guan, Yong[2]; Zheng, Anna[2]; Zhong, Jian-Jiang[1,3]

机构：[1] State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; [2] Key Laboratory for Ultrafine Materials, Ministry of Education, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; [3] State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-chuan Road, Shanghai 200240, China

年份：2011

卷号：31

期号：8

起止页码：1836

外文期刊名：Materials Science and Engineering C

收录：EI(收录号：20114214444820)

语种：英文

外文关键词：Biomedical engineering - Functional polymers - Microwave integrated circuits

摘要：Polyhexamethylene guanidine hydrochloride (PHMG) possesses great potential in the development of covalently bound permanent sterile-surface materials for hospital infection control. This study aimed at evaluating the extensive activity of PHMG and its three novel analogs, including polybutamethylene guanidine hydrochloride, polyoctamethylene guanidine hydrochloride (POMG) and poly(m-xylylene guanidine hydrochloride), against 370 clinical strains, especially 96 isolates of which were antibiotics-resistant. Their in vitro antimicrobial activities were determined by testing the minimal inhibitory concentration (MIC) and time-killing curves. POMG, the novel oligoguanidine had significantly lower MIC values (0.5-16 mg/L) against 370 antibiotics-susceptible and -resistant clinical strains compared to PHMG (1-64 mg/L) and chlorhexidine digluconate (2-64 mg/L). Interestingly, POMG displayed excellent activity against meticillin resistant-Staphylococcus aureus (1-8 mg/L) and -coagulase-negative staphylococci (1-2 mg/L), vancomycin resistant Enterococcus faecium (2-4 mg/L), multidrug resistant Pseudomonas aeruginosa (8-16 mg/L), ceftazidime resistant-Citrobacter spp. (1-4 mg/L) and -Enterobacter spp. (2-4 mg/L). PHMG was especially efficient against methicillin resistant-S. aureus and -coagulase-negative staphylococci (1-8 mg/L). The presented extensive activity of POMG and PHMG against antibiotic-resistant bacteria provides encouraging reference information for the using and further development of cationic guanidine-based polymers in the biomedical material field. ? 2011 Elsevier B.V. All rights reserved.