文献类型：期刊文献

英文题名：Construction of novel benzoxazine-linked covalent organic framework with antimicrobial activity via postsynthetic cyclization

作者：Ma, Q.[1];Liu, X.[1];Wang, H.[1];Zhuang, Q.[1];Qian, J.[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Specially Funct Polymer Mat & Related Tec, Minist Educ, Shanghai 200237, Peoples R China

年份：2022

卷号：23

外文期刊名：MATERIALS TODAY CHEMISTRY

收录：;EI(收录号：20215111354492);WOS:【SCI-EXPANDED(收录号:WOS:000736579100011)】；

基金：This work was financially supported by the National Natural Science Foundation of China (22171086 and 52073091) , the Shanghai Natural Science Foundation (20ZR1414600) .

语种：英文

外文关键词：Benzoxazine; Covalent organic framework; Antimicrobial activity; Modification reaction

摘要：Organic framework materials have shown increasingly promising applications in biomedicine, such as drug delivery and release. In this work, we first synthesized a new hydroxyl-containing imine-linked two-dimensional covalent organic framework (COF) through solvothermal synthesis. Then, the imine group was converted into a benzoxazine group using a cyclization reaction. The results show that the postsynthetic modification did not change the basic framework of the original COF and did not affect the basic properties of the original COF. At the same time, the new benzoxazine group obtained by cyclization gave the COF good antibacterial activity against Escherichia coli and Staphylococcus aureus. The COF efficiency after cyclization was improved, and its antibacterial activity against both bacteria was over 90% compared with the imine-linked COF. Moreover, the benzoxazine-linked COF crystal structure and pore structures were retained, leaving the drug delivery and release functions unaffected. A benzoxazinelinked COF has never been reported because it cannot be synthesized by a direct reaction method. The work in this paper shows that the COFs that cannot be directly synthesized can be obtained through specific postsynthetic modification reactions. This means that more functional COFs can be obtained based on existing COFs, and the diversity of COF types and their potential applications can be further enriched and expanded. (c) 2021 Elsevier Ltd. All rights reserved.