文献类型：期刊文献

英文题名：Enantioselective Synthesis of Polycyclic Indole Derivatives Based on aza-Morita-Baylis-Hillman Reaction

作者：Gao, Yuning[1,2];Xu, Qin[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Adv Mat Lab, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2015

卷号：5

期号：11

起止页码：6608

外文期刊名：ACS Catalysis

收录：;EI(收录号：20154601555987);WOS:【SCI-EXPANDED(收录号:WOS:000364441300043)】；

基金：We are grateful for the financial support from the National Basic Research Program of China (973)-2015CB856603 and the National Natural Science Foundation of China (20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, and 21572052).

语种：英文

外文关键词：chiral phosphine catalysis; asymmetric aza-MBH reaction; polycyclic indole; ring-closing-metathesis; gold catalysis

摘要：A chiral phosphine-catalyzed asymmetric aza-Morita-Baylis-Hillman reaction between indole-derived sulfonyl imines and bis(3-chlorophenyl)methyl acrylate has been developed, giving the desired adducts in good yields and enantiomeric excess values along with the further transformations to polycyclic indoles such as dihydropyrido[1,2-a]indole and dihydropyrazino[1,2-a]indole skeleton.