文献类型：期刊文献

英文题名：Antifouling performance of nano-sized spherical poly(N-hydroxyethyl acrylamide) brush

作者：Qin, Xue[1];Chen, Kaimin[2];Cao, Lan[1];Zhang, Ying[1];Li, Li[1];Guo, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Sch Chem Engn, Shanghai 200237, Peoples R China;[2]Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China;[3]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2017

卷号：155

起止页码：408

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20171803626923);WOS:【SCI-EXPANDED(收录号:WOS:000403738000047)】；

基金：This research was supported by National Natural Science Foundation of China (21504052, 51273063, 21476143), Shanghai Sailing Program (15YF1404800), Shanghai Municipal Education Commission (ZZGCD15032), and SUES startup funding (E1-0501-15-0107).

语种：英文

外文关键词：Antifouling nanoparticles; Poly(N-hydroxyethyl acrylamide); Isothermal titration calorimetry; Fetal bovine serum

摘要：The biomedical applications of nanoparticles are still impeded by the non-specific adsorption of proteins, cells, or others biological species in vivo/in vitro. In this work, poly(N-hydroxyethyl acrylamide) was hired to modify a solid polymer core, polystyrene (PS) nanoparticles, via surface-initiated photo-emulsion polymerization to form nano-sized spherical poly(N-hydroxyethyl acrylamide) brush (PS@PHEAA). Its antifouling ability and stability were investigated by dynamic light scattering (DLS), turbidimetric titration, and isothermal titration calorimetry (ITC). The size of PS@PHEAA was constant as a function of pH, while slightly changed with ionic strength in single protein solution. ITC data confirmed that protein was slightly adsorbed on PS@PHEAA and the ionic strength influenced the adsorption. All characterizations demonstrated that PHEAA layer reduced the interaction between nanoparticles and proteins. Thus, these nanoparticles ideal candidates for future applications in the biomedical field. (C) 2017 Elsevier B.V. All rights reserved.