文献类型：期刊文献

英文题名：A light-regulated synthetic ion channel constructed by an azobenzene modified hydraphile

作者：Yang, Rong-Yan[1];Bao, Chun-Yan[1];Lin, Qiu-Ning[1];Zhu, Lin-Yong[1]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：26

期号：7

起止页码：851

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000359027500009)】；

基金：This work was supported by NNSFC (Nos. 51273064, 21472044), Innovation Program of Shanghai Municipal Education Commission and Fundamental Research Funds for the Central University.

语种：英文

外文关键词：Synthetic ion channel; Light-regulated ion transport; Hydraphiles; Azobenzene photoisomerization; Self-assembly

摘要：Biological ion channels are key molecules for cellular regulation and communication. To mimic the structure and functions of nature ion channels, a new class of light-regulated transmembrane ion channels was reported based on tri(macrocycle) hydraphile and azobenzene photoswitch (hydraphile 1). The liposome-based proton transport assays showed that hydraphile I exhibited excellent transmembrane activity (10, and Y-max arrived 0.7 at 401 mu mo1/L. The successful isomerization of azobenzene moiety was confirmed and qualified by UV and NMR spectra. Upon alternative irradiation of 365 nm UV light and 450 nm visible light, the transmembrane activity of hydraphile I was regulated between 0.35 and 0.5, reversibly. All the obtained results have demonstrated the promise of developing excellent synthetic ion channels with ion gating properties based on simple molecular design. 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.