文献类型：期刊文献

中文题名：羟丙基-β-环糊精对阿魏酸-烟酰胺共晶的包合作用及溶液性质研究

英文题名：Inclusion Effect and Solution Properties of Hydroxypropyl-β-Cyclodextrin on Ferulic-Nicotinamide Cocrystal

作者：井艺霏[1];王小永[1];宁德勇[1];马晓烨[1];宋轲薪[1];黄子昊[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237

年份：2026

卷号：52

期号：1

起止页码：83

中文期刊名：华东理工大学学报(自然科学版)

外文期刊名：Journal of East China University of Science and Technology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(22273022)。

语种：中文

中文关键词：阿魏酸;共晶;环糊精;包合作用;溶液

外文关键词：ferulic acid;cocrystal;cyclodextrin;inclusion effect;solution

摘要：为了研究环糊精类材料的包合作用对植物活性物性质的影响,制备了阿魏酸-烟酰胺(FA-NIC)共晶/羟丙基-β-环糊精(HP-β-CD)包合物,研究了HP-β-CD对FA-NIC共晶的包合作用及溶液性质。相溶解度曲线和Job's曲线表明,FA-NIC共晶与HP-β-CD按照1:1的物质的量之比形成包合物。X射线衍射和傅里叶变换红外光谱结果说明,包合于HP-β-CD疏水内腔的FA-NIC共晶与HP-β-CD的羟基存在氢键作用。由于FA-NIC共晶与HP-β-CD疏水内腔的C—H和糖苷键存在疏水作用,这使得FA表现出更高的紫外吸收强度和荧光强度。相比于纯FA,FA-NIC/HP-β-CD包合物中的FA在水中的平衡溶解度、紫外光照稳定性和DPPH(1,1-二苯基-2-三硝基苯肼)自由基清除率分别提高了5.7倍、17.9个百分点和1倍左右。
To investigate the effect of the inclusion interaction of cyclodextrin-based materials on the properties of plant active substances,ferulic acid-nicotinamide cocrystal(FA-NIC)/hydroxypropyl-β-cyclodextrin(HP-β-CD)inclusion complexes were prepared.The inclusion behavior of HP-β-CD towards FA-NIC cocrystals and the solution properties were studied.Phase solubility curves and Job’s plots indicated that FA-NIC cocrystals form inclusion complexes with HP-β-CD at a molar ratio of 1∶1.Results from X-ray diffraction(XRD)and Fourier transform infrared(FT-IR)spectroscopy demonstrated that hydrogen bonding interactions exist between the FA-NIC cocrystals encapsulated in the hydrophobic cavity of HP-β-CD and the hydroxyl groups of HP-β-CD.Due to the hydrophobic interactions between the C?H bonds and glycosidic bonds in the hydrophobic cavity of HP-β-CD and FA-NIC cocrystals,FA exhibited enhanced ultraviolet(UV)absorption and fluorescence intensity.Compared with pure FA,the equilibrium solubility in water,UV light stability,and DPPH(1,1-diphenyl-2-picrylhydrazyl)free radical scavenging rate of FA in the FA-NIC/HP-β-CD inclusion complex were increased by 5.7-fold,17.9 percentage points,and approximately 1-fold,respectively.