文献类型：期刊文献

英文题名：Photo-Fenton Reaction of Graphene Oxide: A New Strategy to Prepare Graphene Quantum Dots for DNA Cleavage

作者：Zhou, Xuejiao[1];Zhang, Yan[1];Wang, Chong[2];Wu, Xiaochen[1];Yang, Yongqiang[1];Zheng, Bin[2];Wu, Haixia[1];Guo, Shouwu[1];Zhang, Jingyan[2]

机构：[1]Shanghai Jiao Tong Univ, Res Inst Micro Nano Sci & Technol, Minist Educ,Key Lab Thin Film & Microfabricat, Natl Key Lab Micro Nano Fabricat Technol, Shanghai 200240, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Pharm, Shanghai 200237, Peoples R China

年份：2012

卷号：6

期号：8

起止页码：6592

外文期刊名：ACS NANO

收录：;EI(收录号：20123615399740);WOS:【SCI-EXPANDED(收录号:WOS:000307988900010)】；

基金：This work was supported by the NSFC (Nos. 91123011, 90923041, 31070742), the National "973 Program" (No. 2010CB933900), and the State Key Laboratory of Bioreactor Engineering (No. 2060204) of China.

语种：英文

外文关键词：photo-Fenton reaction; graphene quantum dot; DNA cleavage

摘要：Graphene quantum dots (GQDs) are great promising in various applications owing to the quantum confinement and edge effects in addition to their intrinsic properties of graphene, but the preparation of the GQDs in bulk scale is challenging. We demonstrated in this work that the micrometer sized graphene oxide (GO) sheets could react with Fenton reagent (Fe2+/Fe3+/H2O2) efficiently under an UV irradiation, and, as a result, the GQDs with periphery carboxylic groups could be generated with mass scale production. Through a variety of techniques including atomic force microscopy, X-ray photoelectron spectroscopy, gas chromatography, ultraperformance liquid chromatography-mass spectrometry, and total organic carbon measurement, the mechanism of the photo-Fenton reaction of GO was elucidated. The photo-Fenton reaction of GO was initiated at the carbon atoms connected with the oxygen containing groups, and C-C bonds were broken subsequently, therefore, the reaction rate depends strongly on the oxidization extent of the GO. Given the simple and efficient nature of the photo-Fenton reaction of GO, this method should provide a new strategy to prepare GQDs in mass scale. As a proof-of-concept experiment, the novel DNA cleavage system using as-generated GQDs was constructed.