文献类型：期刊文献

英文题名：Extraction optimisation and compositional characterisation of total flavonoids from the Chinese herb tulip: a natural source of antioxidants and anti-inflammatory agents

作者：Ye, Jiafeng[1];Cao, Jiamin[1];Chen, Xian[2];Ma, Jingjing[1];Li, Yangchen[1];Gao, Xia[1];Zhang, Yurui[1];Wang, Chunli[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai, Peoples R China;[2]Eneplus Biotech Co Ltd, Guangzhou, Peoples R China

年份：2024

卷号：38

期号：24

起止页码：4332

外文期刊名：NATURAL PRODUCT RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001105609400001)】；

语种：英文

外文关键词：Chinese herb tulip; total flavonoids; ultrasonic-assisted extraction (UAE); UPLC-Q exactive plus orbitrap MS; antioxidant; anti-inflammatory

摘要：In this study, total flavonoids from the Chinese herb tulip were extracted by ultrasound-assisted extraction (UAE), their main components were analysed and confirmed, and their antioxidant and anti-inflammatory activities were evaluated. The results showed that the extraction rate of total flavonoids from the Chinese herb tulip reached 390.77 +/- 3.88 mg center dot g(-1) after optimisation by one-factor test and response surface methodology. 23 compounds were identified in the solution of total flavonoids from the Chinese herb tulip, including 18 flavonoids such as Hyperoside, Quercetin, Astilbin, etc., and the effects of total flavonoids of the Chinese herb tulip (TFT) on ABTS+ radicals, DPPH radicals, and superoxide anion with a good scavenging rate, good total reducing power, and total antioxidant capacity. Secondly, TFT showed good inhibition of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2).{GRAPHIACAL ABSTRACT}