文献类型：专利

英文题名：New heterocyclic-substituted styrene compound useful for preparing medicine for treating rheumatoid arthritis and in pharmaceutical composition for inhibiting spleen tyrosine kinase

作者：HUANG L;JIN H;LI J;LIU Q;MIU L;XU Y;ZHANG Y

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY;[2]UNIV SUZHOU FIRST AFFILIATED HOSPITAL;[3]CHINESE ACAD SCI SHANGHAI MATERIA MEDICA

申请号：CN103896965-A

申请日：2012-12-27

公开日：2014-07-02

语种：英文

收录：DERWENT

摘要：NOVELTY - A heterocyclic-substituted styrene compound (I), is new. USE - New heterocyclic-substituted styrene compound is useful for preparing medicine for treating rheumatoid arthritis. The pharmaceutical composition is useful as spleen tyrosine kinase inhibitor. ADVANTAGE - The new heterocyclic-substituted styrene compound has strong inhibiting activity of spleen tyrosine kinase. DETAILED DESCRIPTION - A heterocyclic-substituted styrene compound (I) or its salt, is new. R1=1-4C alkoxy; R2=halo; Ar'=6-membered heteroaryl containing heteroatom chosen from N, O and S, or 6-membered aryl optionally substituted with halo, 1-6C alkyl, 1-6C alkoxy, -COOH or -COOR4; A=group chosen from groups of formulae (i)-(iii); R3=H or 1-4C alkyl;and R4=1-4C alkyl. An INDEPENDENT CLAIM is included for pharmaceutical composition, which comprises the compound and carrier and/or additive.