文献类型：期刊文献

英文题名：Solubility and polymorphic forms of antibiotic lasalocid sodium in different organic solvents

作者：Zhang, Xiangyang[1];Zhang, Zhang[2];Yang, Zhiqing[3];Chai, Jian[3];Liu, Chuan[3];Zhang, Liang[3];Zhou, Xinggui[1]

机构：[1]E China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Art, Shanghai 200237, Peoples R China;[3]Hisun Co Ltd, Taizhou, Peoples R China

年份：2014

卷号：374

起止页码：20

外文期刊名：FLUID PHASE EQUILIBRIA

收录：;EI(收录号：20142017721348);WOS:【SCI-EXPANDED(收录号:WOS:000338610200003)】；

基金：We thank the financial support by NSFC (20476026), 111 Project (B08021), Open project of Skloche (08C08) and Hisun Co. Ltd.

语种：英文

外文关键词：Lasalocid sodium; Solid-phase equilibrium; Solvents; Dissolution enthalpy; Dissolution entropy

摘要：The solubilities of lasalocid sodium in five organic solvents including methanol, ethanol, propan-2-ol, ethyl acetate and acetone were determined at temperatures ranging from 283.15 K to 323.15 K at atmospheric pressure using a gravimetric method and three novel polymorphic forms of lasaolocid sodium were observed. van't Hoff equation was used to correlate the experimental solubility data. The calculated values of van't Hoff equation were found to be in good agreement with the experimental data. Further, the dissolution enthalpy and entropy of lasalocid sodium in the corresponding solvents were calculated. (C) 2014 Elsevier B.V. All rights reserved.