文献类型：期刊文献

英文题名：Piezoelectric hydrogel with self-powered biomechanical stimulation enhances bone regeneration

作者：Zhang, Shuyan[1,2];Huang, Lei[3];Chen, Weisin[3];Chen, Qi[1,2];Liu, Xin[1,2];Su, Dihan[3];Xiao, Lan[4];Zhou, Dong[1,2];Zhang, Jian[3];Jiang, Libo[3];Li, Yulin[1,2,5,6]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]Fudan Univ, Zhongshan Hosp, Dept Orthoped Surg, Shanghai 200032, Peoples R China;[4]Griffith Univ, Sch Med & Dent, Gold Coast, Qld 4222, Australia;[5]Shanghai Univ, Wenzhou Inst, Wenzhou Key Lab Tissue Regenerat Med Mat, Wenzhou 325000, Peoples R China;[6]Zhejiang Bailin Biotechnol Co Ltd, Wenzhou 325000, Peoples R China

年份：2025

卷号：195

起止页码：117

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20250817894051);WOS:【SCI-EXPANDED(收录号:WOS:001447854000001)】；

基金：Thanks to Weisin Chen for providing the handmade compression actuator and technical support. The research was supported by the Basic Science Center Program of the National Natural Science Foundation of China (No.T2288102) , the National Key R&D Program of China (2022YFC2405802) , the National Natural Science Foundation of China (51973060, 82272457, 82472396) , the Fujian Provincial Natural Science Foundation of China (2024D031) , and Medical Engineering fund of Fudan University (yg2023-27) , and Shanghai Oriental Talent Program, Major Science and Technology Projects in Ouhai District (G20220206) , Wenzhou Science and Technology Project (ZY2023010) .

语种：英文

外文关键词：Regenerated silk fibroin; Stable piezoelectricity; Mechanical properties; Osseointegration; Angiogenesis

摘要：Large bone defect healing remains a challenge in current clinical treatment, which suggests the need for functional bone repair materials. Piezoelectric materials can generate electrical stimulation under mechanical stress to improve the tissue healing environment, which are emerging candidates for tissue engineering. We created a self-powered piezoelectric hydrogel by simply blending the zinc oxide (ZnO) nanoparticles and regenerating silk fibroin (RSF). Our piezoelectric hydrogel showed controllable and suitable mechanical and piezoelectric properties which could generate electrical stimulation to promote bone tissue healing. Incorporating ZnO into RSF hydrogels not only enhanced their mechanical properties by 1.7 times and increased piezoelectric output by 2.8 times, but also mitigated the degradation rate. In vitro experiments showed that piezoelectric hydrogels significantly promoted osteogenesis differentiation of bone marrow mesenchymal stem cells (BMSCs) and enhanced vascular network reconstitution. In vivo experiments verified the osteogenic and angiogenic potential of ZnO/RSF piezoelectric hydrogels. ZnO/RSF piezoelectric hydrogel, a simple but universal strategy of RSF-based material to generate electric currents by body movement, provides novel insights into the applications of piezoelectric hydrogel. Statement of significance: ZnO/RSF hydrogels with stable piezoelectric properties were prepared by doping ZnO, which can generate stable and continuous electrical signals under pressure. After implantation into the bone defect site, it can promote the osteogenic differentiation of bone marrow mesenchymal stem cells and improve the vasculogenic ability of human umbilical vein endothelial cells, thus promoting the healing of bone tissue.