文献类型：期刊文献

英文题名：Numerical analysis of the relationship between the area of target tissue necrosis and the size of target tissue in liver tumours with pulsed radiofrequency ablation

作者：Zhang, Bing[1];Moser, Michael A. J.[2];Zhang, Edwin M.[3];Luo, Yigang[2];Zhang, Wenjun[1,4,5]

机构：[1]Univ Saskatchewan, Div Biomed Engn, 57 Campus Dr, Saskatoon, SK S7N 5A9, Canada;[2]Univ Saskatchewan, Dept Surg, Saskatoon, SK S7N 5A9, Canada;[3]Univ Alberta, Dept Radiol & Diagnost Imaging, Edmonton, AB, Canada;[4]E China Univ Sci & Technol, Sch Mech & Power Engn, Complex & Intelligent Syst Ctr, Shanghai 200237, Peoples R China;[5]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada

年份：2015

卷号：31

期号：7

起止页码：715

外文期刊名：INTERNATIONAL JOURNAL OF HYPERTHERMIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000369674700002)】；

基金：This article was supported by the Saskatchewan Health Research Foundation (SHRF) through the 'BioNEMS Phase I' grant (grant no. 2539) and the National Natural Science of China (grant no. 51175179). The first author (Bing Zhang) also received financial support from the China Scholarship Council (CSC).

语种：英文

外文关键词：Finite element modelling; liver tumour; pulsed radiofrequency ablation; roll-off; target tissue necrosis

摘要：Purpose: Radiofrequency ablation (RFA) is currently restricted to the treatment of target tissues with a small size (<3cm in diameter). To overcome this problem with RFA, some phenomena need to be understood first. The study presented in this paper investigated the relationship between the area of target tissue necrosis (TTN) and the size of target tissue in pulsed radiofrequency ablation (PRFA). Materials and methods: Liver tumour, one of the common targets of RFA in clinical practice, was used as the target tissue in this study. Two types of pulsed RF power supply methods (half-square and half-sine) and three target tissues with different sizes (25mm, 30mm and 35mm in diameter) were studied using finite element modelling. The finite element model (FEM) was validated by using an in vitro experiment with porcine liver tissue. The first roll-off occurrence or 720 s, whichever occurs first, was chosen as the ablation termination criterion in this study. Results: For each target tissue size, the largest TTN area was obtained using the maximum voltage applied (MVA) without roll-off occurrence. In this study, target tissues with a 25mm diameter can be ablated cleanly but target tissues with 30-mm and 35-mm failed to be ablated. Conclusions: The half-square PRFA could achieve a larger TTN area than the half-sine PRFA. The MVA decreases with an increase in the target tissue diameter in both the half-square PRFA and the half-sine PRFA. The findings of this study are in agreement with the clinical results that lesions (3cm in diameter) have less favourable results from RFA.