文献类型：期刊文献

英文题名：Facile Preparation of Tunicate-Inspired Chitosan Hydrogel Adhesive with Self-Healing and Antibacterial Properties

作者：He, Xiang[1,2];Liu, Ruyue[1,2];Liu, Huiqing[1];Wang, Ruixiao[1];Xi, Zhenhao[1,2];Lin, Yixiang[1];Wang, Jie[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat, Chem Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：13

期号：24

外文期刊名：POLYMERS

收录：;EI(收录号：20215111364945);WOS:【SCI-EXPANDED(收录号:WOS:000737477600001)】；

基金：FundingThis research received no external funding.

语种：英文

外文关键词：facile preparation; tunicate-inspired; chitosan; hydrogel; tissue adhesive

摘要：In order to replace traditional wound treatments such as sutures, tissue adhesives with strong wet tissue adhesion and biocompatibility have attracted more attention to the applications of non-invasive wound closure. Herein, inspired by tunicate adhesive protein, a series of 2,3,4-trihydroxybenzaldehyde (TBA)-modified chitosan hydrogels (CS-TBA-Fe) were prepared by easily mixing the solutions of chitosan-FeCl3 and TBA via the Schiff-base reaction and the coordination between Fe3+ and pyrogallol groups. The gelation time was greatly shortened to only several seconds after induced even trace Fe3+. The hydrogel (CS-TBA-Fe) exhibited ~12-fold enhanced wet tissue adhesion strength (60.3 kPa) over the commercial fibrin glue. Meanwhile, the hydrogel also showed robust adhesion to various substrates such as wood, PMMA, and aluminum. The swelling ratio and rheological property can be simply controlled by changing the concentrations of chitosan, TBA, and Fe3+. Moreover, the hydrogel displayed a rapid and highly efficient self-healing ability and an excellent antibacterial activity against E. coli. The overall results show that the CS-TBA-Fe hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.