文献类型：期刊文献

英文题名：Superfast and Water-Insensitive Polymerization on α-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides Using Tetraalkylammonium Carboxylate as the Initiator

作者：Wu, Yueming[1];Chen, Kang[2];Wu, Xue[2];Liu, Longqiang[2];Zhang, Weiwei[2];Ding, Yun[3];Liu, Shiqi[2];Zhou, Min[2];Shao, Ning[2];Ji, Zhemin[2];Chen, Jiacheng[4];Zhu, Minghui[4];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Frontiers Sci Ctr Mat & Dynam Chem,Res Ctr Biomed, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：60

期号：50

起止页码：26063

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20214511135851);WOS:【SCI-EXPANDED(收录号:WOS:000715917500001)】；

基金：This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (No. 22075078, 21774031, 21861162010, 31800801), the National Key Research and Development Program of China (2016YFC1100401), the Natural Science Foundation of Shanghai (18ZR1410300), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Research program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (22221818014). We also thank the Research Center of Analysis and Test of East China University of Science and Technology for the help with the characterization.

语种：英文

外文关键词：antimicrobial; aqueous polymerization; in situ self-assembly; NCA polymerization; tetraalkylammonium carboxylate

摘要：We design the tetraalkylammonium carboxylate-initiated superfast polymerization on alpha-amino acid N-carboxyanhydrides (NCA) for efficient synthesis of polypeptides. Carboxylates, as a new class of initiator for NCA polymerization, can initiate the superfast NCA polymerization without the need of extra catalysts and the polymerization can be operated in open vessels at ambient condition without the use of glove box. Tetraalkylammonium carboxylate-initiated polymerization on NCA easily affords block copolymers with at least 15 blocks. Moreover, this method avoids tedious purification steps and enables direct polymerization on crude NCAs in aqueous environments to prepare polypeptides and one-pot synthesis of polypeptide nanoparticles. These advantages and the mild polymerization condition of tetraalkylammonium carboxylate-initiated NCA polymerization imply its great potential in functional exploration and application of polypeptides.