文献类型：期刊文献

英文题名：Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S-Nitrosylation Coupling Reaction

作者：Zhang, Wenjie[1,2];Bao, Bingkun[3];Jiang, Fei[1,2,4];Zhang, Yiqing[5,6];Zhou, Renjie[5,6];Lu, Yuezhi[1,2];Lin, Sihan[1,2];Lin, Qiuning[3];Jiang, Xinquan[1,2];Zhu, Linyong[3,5,6]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Prosthodont, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China;[2]Shanghai Jiao Tong Univ, Natl Ctr Stomatol, Natl Clin Res Ctr Oral Dis, Shanghai Key Lab Stomatol,Shanghai Engn Res Ctr A, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Biomed Engn, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China;[4]Nanjing Med Univ, Affiliated Hosp Stomatol, Dept Gen Dent, Jiangsu Key Lab Oral Dis, 140 Han Zhong Rd, Nanjing 210029, Peoples R China;[5]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg Technol, State Key Lab Bioreactor Engn, Optogenet & Synthet Biol Interdisciplinary Res Ct, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[6]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：33

期号：48

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20214010979768);WOS:【SCI-EXPANDED(收录号:WOS:000703012900001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Program Nos. 2019YFA0110500, 2016YFC1102900, and 2019YFA0904800), the National Natural Science Foundation of China (Grant Nos. 81921002, 82022015, 32071361, 22022506, 81991505, and 21937004), and Shanghai Rising-Star Program (Program No. 20QA1405700). All of the animal experiments in this work were carried out approved by the Institute for Laboratory Animal Research of the Ninth People's Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine (approval number: SH9H-2019-A167-1). The pork meat and tissue used were obtained from a market.

语种：英文

外文关键词：hydrogels; o-nitrobenzyl photocages; oral mucosal diseases; photo-crosslinking; tissue adhesives

摘要：The wet and highly dynamic environment of the mouth makes local treatment of oral mucosal diseases challenging. To overcome this, a photo-crosslinking hydrogel adhesive is developed inspired by the success of light-curing techniques in dentistry. The adhesive operates on a fast (within 5 s) phototriggered S-nitrosylation coupling reaction and employs imine anchoring to connect to host tissues. Unlike other often-used clinical agents that adhere weakly and for short durations, this thin, elastic, adhesive, and degradable cyclic o-nitrobenzyl-modified hyaluronic acid gel protects mucosal wounds from disturbance by liquid rinsing, oral movement, and friction for more than 24 h. The results from both rat and pig oral mucosa repair models demonstrate that this new gel adhesive creates a favorable microenvironment for tissue repair and can shorten tissue healing time. This study thus illustrates a therapeutic strategy with the potential to advance the treatment of oral mucosal defects in the clinic.