文献类型：期刊文献

英文题名：Morphology Tuning of Aggregation-Induced Emission Probes by Flash Nanoprecipitation: Shape and Size Effects on in Vivo Imaging

作者：Wang, Mingwei[1];Xu, Yisheng[1,4];Liu, Yajing[3];Gu, Kaizhi[2];Tan, Jinchao[3];Shi, Ping[3];Yang, Dahai[3];Guo, Zhiqian[2];Zhu, Weihong[2];Guo, Xuhong[1,4];Stuart, Martien A. Cohen[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2018

卷号：10

期号：30

起止页码：25186

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20182805542956);WOS:【SCI-EXPANDED(收录号:WOS:000440956000027)】；

基金：This work was supported by the National Natural Science Foundation of China (NSFC) for Science Center Program (21788102), NSFC (21676089, 21476143), Excellent Young Scholars (21622602) NSFC/China, Distinguished Young Scholars (21325625) NSFC/China, Young Scholars (21706074) NSFC/China, Shanghai talent development fund (2017038), Oriental Scholarship of Scientific Committee of Shanghai (14ZR1409700 and 15XD1501400), and Funda-mental Research Funds for the Central Universities (222201313010, 222201314029, and 222201717013).

语种：英文

外文关键词：aggregation-induced emission; quinolinemalononitrile; nanoparticle morphology; flash nanoprecipitation; in vivo imaging; fluorescence

摘要：Aggregation-induced emission (AIE) imaging probes have recently received considerable attention because of their unique property of high performance in the aggregated state and their imaging capability. However, the tendency of ALE molecules to aggregate into micron long irregular shapes, which significantly limits their application in vivo, is becoming a serious issue that needs to be addressed. Here, we introduce a novel engineering strategy to tune the morphology and size of AIE nanoaggregates, based on flash nanoprecipitation (FNP). Quinolinemalononitrile (ED) is encapsulated inside properly selected amphiphilic block copolymers of varying concentration. This leads to a variety of ED particle morphologies with different sizes. The shape and size are found to have strong influences on tumor targeting both in vitro and in vivo. The current results therefore indicate that the FNP method together with optimal choice of an amphiphilic copolymer is a universal method to systematically control the aggregation state of AIE materials and hence tune the morphology and size of AIE nanoaggregates, which is potentially useful for precise imaging at specific tumor sites.