文献类型：期刊文献

英文题名：Synthesis of pyrazoles from sulfonyl hydrazone and benzyl acrylate under transition-metal-free conditions

作者：Hao, Liqiang[1];Wang, Zhichao[1];Wang, Yangyang[1];Yang, Zhaoziyuan[1];Liu, Xian[1];Xu, Xiaobo[1];Ji, Yafei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2023

卷号：21

期号：37

起止页码：7611

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20233914774319);WOS:【SCI-EXPANDED(收录号:WOS:001060413700001)，CCR-EXPANDED(收录号:WOS:001060413700001)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.

语种：英文

外文关键词：Transition metals

摘要：Pyrazoles as an important class of heterocyclic compounds, are widely found in pharmaceuticals and bioactive natural products. Herein we report a [3 + 2] cycloaddition reaction for the synthesis of a series of pyrazoles, with the yield up to 77%. This approach exhibits many notable features, such as convenient operating conditions, excellent functional group compatibility and readily accessible raw materials, providing an alternative route for the construction of pyrazole derivatives. DBU-mediated [3 + 2] cycloaddition reaction for the synthesis of pyrazoles. It is noteworthy that this reaction constructed two new C-N bonds and a new C-C bond at the same time, providing a new door for the construction and functionalization of pyrazole scaffolds.