文献类型：期刊文献

英文题名：Radiofrequency ablation for liver tumors abutting complex blood vessel structures: treatment protocol optimization using response surface method and computer modeling

作者：Fang, Zheng[1,2];Wei, Hongjun[3];Zhang, Hanwei[3];Moser, Michael A. J.[4];Zhang, Wenjun[1];Qian, Zhiqin[3];Zhang, Bing[2]

机构：[1]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK, Canada;[2]Shanghai Univ, Sch Mechatron Engn & Automat, Intelligent Energy Based Tumor Ablat Lab, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai, Peoples R China;[4]Univ Saskatchewan, Dept Surg, Saskatoon, SK, Canada

年份：2022

卷号：39

期号：1

起止页码：733

外文期刊名：INTERNATIONAL JOURNAL OF HYPERTHERMIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000799722100001)】；

基金：This article was supported by Error! Hyperlink reference not valid. through a funding grant [Grant No. 81801795] to the corresponding author (BZ), RUH Foundation Research Grant [Grant No. R210211] to WZ and the Program of Production, Research and Development of Minhang District of Shanghai through a funding grant [Grant No. 2019MHC066] to the corresponding author (ZQ).

语种：英文

外文关键词：Radiofrequency ablation; liver tumor; blood vessels; heat sink; treatment protocol optimization

摘要：Objective: To achieve a result of a large tumor ablation volume with minimal thermal damage to the surrounding blood vessels by designing a few clinically-adjustable operating parameters in radiofrequency ablation (RFA) for liver tumors abutting complex vascular structures. Methods: Response surface method (RSM) was employed to correlate the ablated tumor volume (R-a) and thermal damage to blood vessels (D-t) based on RFA operating parameters: ablation time, electrode position, and insertion angle. A coupled electric-thermal-fluid RFA computer model was created as the testbed for RSM to simulate RFA process. Then, an optimal RFA protocol for the two conflicting goals, namely (1) large tumor ablation and (2) small thermal damage to the surrounding blood vessels, has been achieved under a specific ablation environment. Results: Linear regression analysis confirmed that the RFA protocol significantly affected R-a and D-t (the adjusted coefficient of determination R-adj(2) = 93.61% and 95.03%, respectively). For a proposed liver tumor scenario (liver tumor with a dimension of 4 x3x2.9 cm(3) abutting a complex vascular structure), an optimized RFA protocol was found based on the regression results in RSM. Compared with a reference RFA protocol, in which the electrode was centered in the tumor with a 12-min ablation time, the optimized RFA protocol has increased R-a from 98.1% to 99.6% and decreased D-t from 4.1% to 0.4%, achieving nearly the complete ablation of proposed liver tumor and ignorable thermal damages to vessels. Conclusion: This work showed that it is possible to design a few clinically-adjustable operating parameters of RFA for achieving a large tumor ablation volume while minimizing thermal damage to the surrounding blood vessels.