文献类型：期刊文献

英文题名：In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration

作者：Wu, Zhaoying[1];Tang, Tingting[2];Guo, Han[3];Tang, Songchao[1];Niu, Yunfei[4];Zhang, Jue[1];Zhang, Wenjing[1];Ma, Rui[2];Su, Jiacan[4];Liu, Changsheng[1];Wei, Jie[1]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants, Dept Orthopaed Surg,Sch Med, Shanghai 200011, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China;[4]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China

年份：2014

卷号：120

起止页码：38

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20142417810731);WOS:【SCI-EXPANDED(收录号:WOS:000339774500006)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (No. 81271705, 81000799 and 31100680), the Nano special program of Science and Technology Development of Shanghai (No. 12nm0500400), the Key Medical Program of Science and Technology Development of Shanghai (No. 12441903600), and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implants.

语种：英文

外文关键词：esoporous magnesium silicate; Water absorption; Degradation; Bioactive materials; Cytocompatibility

摘要：Mesoporous magnesium silicate (m-MS) was synthesized, and the in vitro degradability, bioactivity and primary cell responses to m-MS were investigated. The results suggested that the m-MS with mesoporous channels of approximately 5 nm possessed the high specific surface area of 451.0 m(2)/g and a large specific pore volume of 0.41 cm(3)/g compared with magnesium silicate (MS) without mesopores of 75 m2/g and 0.21 cm(3)/g, respectively. The m-MS was able to absorb a large number of water, with water absorption of 74% compared with 26% for MS. The m-MS was also degradable in a Tris-HCI solution, with a weight loss ratio of 40 wt% after a 70-day immersion period. The m-MS exhibited good in vitro bioactivity, inducing apatite formation on its surfaces after soaking in simulated body fluid (SBF) at a faster rate than observed for MS. The m-MS surface clearly promoted the proliferation and differentiation of MC3T3-E1 cells, and their normal cell morphology indicated excellent cytocompatibility. This study suggested that mesoporous magnesium silicate with a high specific surface area and pore volume had suitable degradability and good bioactivity and biocompatibility, making it an excellent candidate biomaterial for the induction of bone regeneration. (C) 2014 Elsevier B.V. All rights reserved.