文献类型：期刊文献

英文题名：Well-Defined Selenium-Containing Aliphatic Polycarbonates via Lipase-Catalyzed Ring-Opening Polymerization of Selenic Macrocyclic Carbonate Monomer

作者：Wei, Chao[1];Xu, Yue[1];Yan, Bingkun[1];Hou, Jiaqian[1];Du, Zhengzhen[1];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat & Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2018

卷号：7

期号：3

起止页码：336

外文期刊名：ACS MACRO LETTERS

收录：;EI(收录号：20181204935244);WOS:【SCI-EXPANDED(收录号:WOS:000428220200012)】；

基金：Financial support from the National Key Research and Development Program (2016YFC1100700) are gratefully acknowledged.

语种：英文

外文关键词：Carbonation - Molecular weight distribution - Polyethylene oxides - Scaffolds (biology) - Controlled drug delivery - Copolymerization - Polycarbonates - Catalysts - Living polymerization - Polyethylene glycols - Ring opening polymerization

摘要：The synthesis of well-defined, biodegradable selenium-containing polymers remains a formidable challenge in polymer chemistry. Herein, a selenic cyclic carbonate dimer monomer (M-se) was developed to generate well-defined, biodegradable aliphatic polycarbonates with selenide functionality on the backbone. The monomer was synthesized via the intermolecular cyclization of di(1-hydroxyethylene) selenide and diphenyl carbonate with lipase CA as catalysts in a mass of anhydrous toluene with very dilute monomer concentration. Then living ring-opening polymerization (ROP) was executed by solution method using the same lipase CA as catalysts. Similarly, the copolymerizations with commercial trimethylene carbonate (TMC) generated random copolymers demonstrated by C-13 NMR, regulating the density of selenium functional groups. The resulting polymers exhibited a living polymerization characteristic, as evidenced by polymerization kinetics, predictable molecular weights, narrow molecular-weight distribution, and controlled copolymer compositions. Using hydrophilic macroinitiators (PEG), amphiphilic di/triblock copolymers could be obtained, suggesting their potential as controlled drug delivery system (DDS) and hydrogel scaffolds for tissue engineering.