文献类型：期刊文献

英文题名：Enantioselective Synthesis of Functionalized Chiral Diarylalkanes via Chiral Phenanthroline-Cu-Catalyzed Alkynylation and Amination of Six-Membered Cyclic Diaryliodonium Salts

作者：Gao, Jun[1];Gao, Xiang[1];Tan, Jing[1];Cen, Shouyi[1];Zhang, Zhipeng[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, Shanghai 200237, Peoples R China

年份：2026

卷号：16

期号：15

起止页码：14761

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20263321301329);Scopus(收录号：2-s2.0-105047254303);WOS:【SCI-EXPANDED(收录号:WOS:001828062200001)】；

基金：We thank the Research Center of Analysis and Test, East China University of Science and Technology, for the help with the characterization. We acknowledge the National Natural Science Foundation of China (22371072, 22571082, and 22501081), the Natural Science Foundation of Shanghai (24ZR1415000), the Fundamental Research Funds for the Central Universities (222201717003, JKVJ1251010, SLJ13233303, and YJ0142232), the Science and Technology Commission of Shanghai Municipality (24DX1400200), the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM404) for their generous financial support.

语种：英文

外文关键词：enantioselective; copper-catalyzed; chiral diarylalkane; alkynylation; amination; cyclic diaryliodonium salts

摘要：Highly functionalized chiral diarylalkanes containing C(sp2)-I bonds and bearing either various alkyne groups or N-alkoxy sulfonamide groups have been synthesized in up to 99% yield with up to a 98:2 enantiomeric ratio (er) through chiral phenanthroline ligand-enabled Cu-catalyzed asymmetric alkynylation and amination of six-membered cyclic diaryliodonium salts. Furthermore, the amination products can be readily converted to biologically relevant chiral 3,4-dihydroquinolin-2(1H)-ones in one step, with nearly complete retention of enantiopurity.