文献类型：期刊文献

中文题名：戊二醛一步固化法制备氟尿嘧啶壳聚糖微球

英文题名：One-step Solidification with Glutaraldehyde in Preparation of Fluorouracil-loaded Chitosan Microspheres

作者：杨春梅[1,2];顾磊[1];孙怡[1];孙军[1];高峰[1]

机构：[1]华东理工大学药学院药剂教研组,上海200237;[2]上海市医药学校,上海200135

年份：2010

卷号：41

期号：1

起止页码：23

中文期刊名：中国医药工业杂志

外文期刊名：Chinese Journal of Pharmaceuticals

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：上海市科委专项基金(0852nm05900);111学科创新引智计划资助(B07023)

语种：中文

中文关键词：壳聚糖;微球制剂;氟尿嘧啶;固化法;戊二醛

外文关键词：chitosan; microsphere; fluorouracil; solidification; glutaraldehyde

摘要：以壳聚糖为载体,戊二醛为交联剂,氟尿嘧啶为模型药物,采用一步固化法制备氟尿嘧啶壳聚糖微球制剂。以外观和包封率为指标优化了处方,并考察了交联剂浓度和交联时间对微球体外释放行为及溶胀度的影响。采用扫描电镜和红外光谱对微球结构进行表征。所得载药微球的载药量和包封率为33.5%、51.2%,平均粒径为(6.8±1.8)μm,30 min时突释量为33.5%。
Fluorouracil-loaded chitosan microspheres were prepared by one-step solidification technique with chitosan as drug carrier, glutaraldehyde as crosslinking agent. The preparation was optimized by single factor test with the appearance and encapsulation efficiency as the indexes. The effects of crosslinking agent concentration and crosslinking time on the in vitro release and swelling ratio of the microspheres were investigated. The structure of the microsphere was analyzed by scanning electron microscopy and infrared spectrum. The drug loading and encapsulation efficiency of fluorouracil-loaded chitosan microspheres were 33.5 % and 51.2 % with mean diameter of （6.8 ± 1.8） μm, and the burst release at 30 min was 33.5% at 30 min.