文献类型：期刊文献

英文题名：Pore expansion of highly monodisperse phenylene-bridged organosilica spheres for chromatographic application

作者：Zhang, Yongping[1];Jin, Yu[1];Yu, Hui[1];Dai, Peichun[1];Ke, Yanxiong[1];Liang, Xinmiao[1]

机构：[1]E China Univ Sci & Technol, Minist Educ, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2010

卷号：81

期号：3

起止页码：824

外文期刊名：TALANTA

收录：;EI(收录号：20101112769583);WOS:【SCI-EXPANDED(收录号:WOS:000276877500013)】；

基金：This work was sponsored by the start-up fund from East China University of Science and Technology, 111 Project (No. B07023) and NSF of China (Grant No. 20601025).

语种：英文

外文关键词：Phenylene-bridged; Hybrid organosilica; Spheres; Pore expansion; HPLC

摘要：Monodisperse phenylene-briclgecl organosilica spheres show great potential as chromatographic stationary phase. In this paper, the tunable particle size of monodisperse phenylene-bridged organosilica spheres were prepared by co-condensing different proportion of 1,4-bis(triethoxysilyl)benzene (1,4-BTEB) and tetraethylorthosilicate (TEOS), and then pore size was expanded by two-step post-synthesis hydrothermal treatments using N,N-dimethyldecylamine (DMDA)/dodecylamine (DDA) and tris-(hydroxymethyl)-aminomethane (TRIS) in turn. Phenylene-bridged organosilica spheres with particle size of 3.0-3.5 mu m and pore size of 85 angstrom were further surface modified by C-18 group and tested in reversed-phase high performance liquid chromatography (RP-HPLC). The primary chromatographic results demonstrated that C-18 bonded phenylene-bridged organosilica stationary phase has high retention and good chemical stability in the high pH mobile phase, which indicated that the phenylene-bridged organosilica can be used for HPLC packing supports. (C) 2010 Elsevier B.V. All rights reserved.