文献类型：期刊文献

中文题名：噻二唑基-3(2H)-哒嗪酮类化合物的合成及生物活性

英文题名：Synthesis and Biological Activities of New Thiadiazolyl 3(2H)-pyridazinones

作者：曹松[1];曲玉成[1];宋恭华[1];钱旭红[1];黄青春[1];卢德力[1]

机构：[1]华东理工大学药物化工研究所上海市化学生物学(芳香杂环)重点实验室,上海200237

年份：2004

卷号：6

期号：2

起止页码：68

中文期刊名：农药学学报

外文期刊名：Chinese Journal of Pesticide Science

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

基金：上海市科委攻关项目(项目编号:034319250);上海市重点学科资助.

语种：中文

中文关键词：噻二唑;哒嗪酮;合成;生物活性

外文关键词：thiadiazolyl pyridazinone; synthesis; insecticidal activities

摘要：将取代的二酰基肼环合后,得到中间体2-芳基-5-氯甲基-1,3,4-噻二唑,然后与2-叔丁基-4-氯-5-羟基-3(2H)-哒嗪酮反应,合成了8个未见文献报道的含噻二唑基哒嗪酮类化合物,其化学结构经1HNMR、高分辩质谱和元素分析确认。生物活性测试结果表明,部分化合物对粘虫P.separateW.有较好的抑制生长活性,其中化合物3b的EC50值为21mg/L。
Eight new thiadiazolyl 3(2H)-pyridazinones compounds were synthesized by the (reaction) of 2-tert-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinones with 5-aryl-2-chloromethyl-(1,3,4)-oxadiazoles which were prepared by the cyclization of N-chloroacetyl-N′-aroylhydrazines. The structure of the title compounds were confirmed by ()~1H NMR, HR mass spectra and elemental analysis. Their biological activities were examined and some of them exhibited good activities against (Pseudaletia) separate Walker. The EC_(50) of 3b was 21 mg/L.