文献类型：期刊文献

英文题名：Inverse-electron-demand Diels-Alder approach to densely substituted bicyclo[3.2.2]nonanes: Discovery of an autophagy regulator

作者：Li, Jiulong[1,2,3];Ren, Pengxin[1,2,3];Wang, Lin[4];Zhang, Yuting[4];Yang, Peng[1,2];He, Weiwei[4];Li, Ang[3]

机构：[1]Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China;[2]Zhengzhou Univ, Henan Inst Adv Technol, Zhengzhou 450001, Peoples R China;[3]Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Chinese Acad Sci, State Key Lab Chem Biol, Shanghai 200032, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2026

卷号：37

期号：5

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001691420200008)】；

基金：We thank Yali Wu and Dr. Mengyu Ba for discussion. This work was supported by the National Natural Science Foundation of China (Nos. 22477026 , 21931014 , 22101268 , and U24A20807) , Chinese Academy of Sciences (Nos. YSBR-095 , XDB1060000 , XBZG-ZDSYS-202303) , Natural Science Foundation of Henan (No. 242300420180) , and Science and Technology Commission of Shanghai Municipality (No. JCYJ-SHFY-2022-005) . A.L. is grateful to the New Cornerstone Science Foundation for the Xplorer Prize.

语种：英文

外文关键词：Bicyclo[3.2.2]nonane; Benzo[2,3]tropone; Inverse-electron-demand Diels-Alder reaction; Autophagy regulation

摘要：Natural products bearing a bicyclo[3.2.2]nonane motif pose a considerable challenge to chemical synthesis. We developed a europium-promoted inverse-electron-demand Diels-Alder reaction of benzo[2,3]tropone derivatives with electron-rich olefins, which offers an expeditious approach to densely substituted bicyclo[3.2.2]nonanes. This method enabled the concise synthesis of a tetracyclic amine, subsequently identified as a downstream suppressor of autophagy. (c) 2026 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.