文献类型：期刊文献

英文题名：Synthesis and pH-Responsive Assembly of Methoxy Poly(ethylene glycol)-b-poly(ε-caprolactone) with Pendant Carboxyl Groups

作者：Zhang, Yan[1,2];Li, Jinhong[1];Du, Zhengzhen[1];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

年份：2014

卷号：52

期号：2

起止页码：188

外文期刊名：JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

收录：;EI(收录号：20135117098929);WOS:【SCI-EXPANDED(收录号:WOS:000328051600005)】；

基金：Financial support from the National Natural Science Foundation of China (20804015, 21274039), the Fundamental Research Funds for the Central Universities (WD0913008), Shanghai Key Laboratory Project (08DZ2230500) and Basic Research Key Program Project of Commission of Science and Technology of Shanghai (12JC1403000, 12JC1403100) are gratefully acknowledge.

语种：英文

外文关键词：hydrophilic polymers; micelles; pendant carboxyl groups; pH-responsive; poly(epsilon-caprolactone); polyesters; water-soluble

摘要：pH-responsive methoxy poly(ethylene glycol)-b-poly(epsilon-caprolactone) bearing pendant carboxyl groups mPEG-b-P(2-CCL-co-6-CCL) was synthesized based on our newly monomer benzyloxycarbonylmethly functionalized epsilon-caprolactone. Their structure was confirmed by H-1 NMR, C-13 NMR, and Fourier transform infrared spectrum spectra. In addition, SEC results indicated that the copolymers had a relatively narrow polydispersity. WXRD and DSC demonstrated that the introduction of carboxymethyl groups had significant effect on the crystallinity of the copolymers. Furthermore, the solution behavior of mPEG-b-P(2-CCL-co-6-CCL) has been studied by various methods. The results indicated that mPEG-b-P(2-CCL-co-6-CCL) had a rich pH-responsive behavior and the micelles could be formed by pH induction, and the mPEG-b-P(2-CCL-co-6-CCL) could existed as unimers, micelles or large aggregates in different pH range accordingly. The mechanism of which was supposed to depend on the counteraction between the hydrophobic interaction from PCL and the ionization of the carboxyl groups along the polymer chain. Moreover, the mPEG-b-P(2-CCL-co-6-CCL) copolymers displayed good biocompatibility according to the preliminary cytotoxicity study. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 188-199