文献类型：期刊文献

英文题名：Occurrence and removal of antibiotics, antibiotic resistance genes, and bacterial communities in hospital wastewater

作者：Yao, Shijie[1];Ye, Jianfeng[2];Yang, Qing[2];Hu, Yaru[1];Zhang, Tianyang[3,4];Jiang, Lei[5];Munezero, Salvator[1];Lin, Kuangfei[1];Cui, Changzheng[1,3]

机构：[1]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[2]Shanghai Acad Environm Sci, Shanghai 200233, Peoples R China;[3]Shanghai Inst Pollut Control & Ecol Secur, Shanghai 200092, Peoples R China;[4]Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Key Lab Yangtze Water Environm,Minist Educ, Shanghai 200092, Peoples R China;[5]Natl Engn Res Ctr Urban Water Resources, Shanghai 200082, Peoples R China

年份：2021

卷号：28

期号：40

起止页码：57321

外文期刊名：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

收录：;EI(收录号：20242616389043);WOS:【SCI-EXPANDED(收录号:WOS:000658101100006)】；

基金：This work was supported by the Science and Technology Commission of Shanghai Municipality (No. 20dz1200800) and China National Major Science and Technology Program for Water Pollution Control and Treatment (No. 2017ZX07402003).

语种：英文

外文关键词：Antibiotics; beta-lactams; Antibiotic resistance genes; Hospital wastewater treatment plants; Pathogenic bacteria; Disinfection

摘要：Hospital wastewater contains a variety of human antibiotics and pathogens, which makes the treatment of hospital wastewater essential. However, there is a lack of research on these pollutants at hospital wastewater treatment plants. In this study, the characteristics and removal of antibiotics and antibiotic resistance genes (ARGs) in the independent treatment processes of hospitals of different scales (primary hospital, H1; secondary hospital, H2; and tertiary hospital, H3) were investigated. The occurrence of antibiotics and ARGs in wastewater from three hospitals varied greatly. The first-generation cephalosporin cefradine was detected at a concentration of 2.38 mu g/L in untreated wastewater from H1, while the fourth-generation cephalosporin cefepime had the highest concentration, 540.39 mu g/L, at H3. Ofloxacin was detected at a frequency of 100% and had removal efficiencies of 44.2%, 51.5%, and 81.6% at H1, H2, and H3, respectively. The highest relative abundances of the beta-lactam resistance gene bla(GES-1) (1.77x10(-3) copies/16S rRNA), the quinolone resistance gene qnrA (8.81x10(-6) copies/16S rRNA), and the integron intI1 (1.86x10(-4) copies/16S rRNA) were detected in the treated wastewater. The concentrations of several ARGs were increased in the treated wastewater (e.g. bla(OXA-1), bla(OXA-10), and bla(TEM-1)). Several pathogenic or opportunistic bacteria (e.g. Acinetobacter, Klebsiella, Aeromonas, and Pseudomonas) were observed at high relative abundances in the treated wastewater. These results suggested the co-occurrence of antibiotics, ARGs, and antibiotic-resistant pathogens in hospital wastewater, and these factors may spread into the receiving aquatic environment.