文献类型：期刊文献

英文题名：Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters

作者：Yao, Hanlin[1];Wan, Li[1];Guo, Yahui[1];Mao, Yuxin[1];Xin, Zhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：26

期号：5

起止页码：1365

外文期刊名：ORGANIC PROCESS RESEARCH & DEVELOPMENT

收录：;EI(收录号：20221812066163);WOS:【SCI-EXPANDED(收录号:WOS:000823485400001)】；

基金：The authors would like to acknowledge the financial support from the Program of Leading Talents (2013) .

语种：英文

外文关键词：2,2'-methylene-bis(4; 6-di-tert-butylphenol) phosphate chloride; condensation reaction; calorimetry; strong heat release; kinetics; thermal risk assessment

摘要：From the safety point of view, thermal risk analysis in the process industry is generally of significant importance and often requires calorimetric and kinetic modeling. These techniques were applied for the first time in the study of a highly exothermic condensation reaction, which is used to prepare 2,2'-methylene-bis(4,6-di-tert-butylphenol) phosphate chloride, a quite important intermediate in the fine chemical industry. The thermodynamics properties such as reaction heat, adiabatic temperature rise, and specific heat capacity of the synthesis reaction were experimentally investigated under isothermal conditions using a robust process analytical technology-based in-line reaction calorimeter EasyMax. A kinetic correlation model was developed based on the calorimetry and subsequently verified. This exhibited a much more efficient and convenient way to study the reaction kinetics compared with the conventional off-line determination of molar concentration or conversion. An accelerating rate calorimeter was used to reveal the thermal controllability of the reaction system as well as some potential hazards. The thermal and kinetic parameters lay a solid foundation for the design and safe operation of reactors. The related methods are also anticipated to be extended to a wide range of similar highly exothermic reactions.