文献类型：期刊文献

中文题名：蛋氨酸的连续结晶过程

英文题名：Continuous Crystallization Process of Methionine

作者：李涛[1];任国宾[2]

机构：[1]中国医药工业研究总院上海医药工业研究院,创新药物与制药工艺国家重点实验室,上海200040;[2]华东理工大学药学院,上海200237

年份：2014

卷号：45

期号：10

起止页码：973

中文期刊名：中国医药工业杂志

外文期刊名：Chinese Journal of Pharmaceuticals

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

语种：中文

中文关键词：蛋氨酸;连续结晶;粒度分布;动力学

外文关键词：methionine; continuous crystallization; size distribution; dynamics

摘要：工业结晶分为间歇和连续两种操作方式。相较于间歇结晶,连续结晶具有设备占地面积小、生产效率高、产品质量可控性高等优点。本文研究蛋氨酸的连续结晶过程,结果表明,与间歇结晶产品相比,蛋氨酸连续结晶产品粒度大且分布均匀,聚结现象明显改善;同时测定了蛋氨酸连续结晶动力学参数,为产业化及结晶器设计提供支持。
Crystallization can be carried out in batch or continuous process. The continuous crystallization process has the advantages of small equipment size, improved process efficiency and crystal characteristics easy to control. Continuous crystallization of methionine was studied in this paper. The results indicated that compared with the products of batch crystallization, continuous crystallization resulted in bigger crystal size, narrowsize distribution, significantly reduced agglomeration. Dynamics of continuous crystallization of methionine was determined as to provide some references for the scale-up and crystallizer design.