文献类型：期刊文献

英文题名：Cascade Reaction for the Synthesis of Carbolines from O-Methylketoximes and Styrenes via Palladium-Catalyzed C-H Activation and Sequential Annulation

作者：Fu, Xiao-Pan[1];Tang, Shi-Biao[1];Yang, Jin-Yue[1];Zhang, Li-Li[1];Xia, Cheng-Cai[2];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Inst Pharmacol, Tai An 271016, Shandong, Peoples R China

年份：2019

卷号：2019

期号：34

起止页码：5974

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000479610700001)，CCR-EXPANDED(收录号:WOS:000479610700001)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project Nos. 21676088 and 21476074) for financial support.

语种：英文

外文关键词：Carbolines; Dual C-C; C-N formation; Annulation; Styrenes; Palladium

摘要：A novel cascade reaction has been described for the synthesis of Carbolines via palladium-catalyzed successive C-C/C-N formation from O-methylketoximes and styrenes. The oxime ether auxiliary not only serves as a traceless directing group, but is also partly transformed into the value-added pharmacophore in a two-step, one-pot fashion.