文献类型：期刊文献

英文题名：Efficient Reduction of Oxazolyl-bearing Secondary Anilides to Amines by Nickel-catalyzed Hydrosilylation

作者：Zhou, Jian[1];Bo, Xiaofan[1];Wan, Li[1];Xin, Zhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：9

期号：5

起止页码：818

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000520522400001)】；

基金：We acknowledge the Fundamental Research Funds for the Central Universities (50321011917025 and YA0127104) for their financial support.

语种：英文

外文关键词：nickel; hydrosilylation; amides; oxazoline; reduction

摘要：A convenient procedure for the catalytic hydrosilylation of secondary anilides bearing an oxazolyl group has been developed. In the presence of inexpensive NiBr2, the reduction of functionalized secondary amides with nontoxic and air-stable TMDS proceeded smoothly to give the corresponding functionalized amines. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for several sensitive functional groups such as halo, ester and nitro groups.