文献类型：专利

英文题名：Preparing 2-methyl-2-aryl-propyl carboxylate derivative used as pharmaceutical intermediate, involves performing Friedel-Crafts alkylation reaction between aromatic hydrocarbon and carboxylate derivative in presence of mixed catalyst

作者：WU F;ZHAO M;GUO F;NIU D

机构：[1]UNIV EAST CHINA SCI&TECHNOLOGY

申请号：CN101823958-A

申请日：2009-03-02

公开日：2010-09-08

语种：英文

收录：DERWENT

摘要：NOVELTY - 2-Methyl-2-aryl-propyl carboxylate derivative (I) preparation involves performing Friedel-Crafts alkylation reaction between aromatic hydrocarbon and carboxylate derivative (II) in presence of mixed catalyst. USE - Method for preparing 2-Methyl-2-aryl-propyl carboxylate derivative (claimed) used as pharmaceutical intermediate. ADVANTAGE - The 2-methyl-2-aryl-propyl carboxylate derivative (I) preparation method is simple. DETAILED DESCRIPTION - 2-Methyl-2-aryl-propyl carboxylate derivative (I) preparation involves performing Friedel-Crafts alkylation reaction between aromatic hydrocarbon and carboxylate derivative (II) in presence of mixed catalyst. Ar=phenyl or naphthyl (both electron donating group substituted), electron donating group substituted 7-membered heterocyclyl containing N or O optionally fused with O containing benzo ring or heteroaryl; and R=1-6C alkyl.