文献类型：期刊文献

英文题名：Advances in microbial production of medium-chain dicarboxylic acids for nylon materials

作者：Li, Guohui[1,3];Huang, Dixuan[1,3];Sui, Xue[1,3];Li, Shiyun[1,3];Huang, Bing[2,4,5];Zhang, Xiaojuan[1,3];Wu, Hui[2,4,5];Deng, Yu[1,3]

机构：[1]Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol NELCF, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Jiangnan Univ, Jiangsu Prov Res Ctr Rioact Prod Proc Technol, Wuxi, Jiangsu, Peoples R China;[4]Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[5]China Natl Light Ind Council, Key Lab Biobased Mat Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：5

期号：2

起止页码：221

外文期刊名：REACTION CHEMISTRY & ENGINEERING

收录：;EI(收录号：20200708181030);WOS:【SCI-EXPANDED(收录号:WOS:000511383500002)】；

基金：This work was supported by grants from the National Key R&D Program of China (2018YFA0901401), the National Natural Science Foundation of China (21776083, 21877053, 31600044), the National Key Research and Development Program of China (Grant No. 2017YFB0309302), the National First-Class Discipline Program of Light Industry Technology and Engineering (LITE2018-24), the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP), the Fundamental Research Funds for the Central Universities (JUSRP51705A, JUSRP11964, 22221818014), the Fok Ying-Tong Education Foundation, China (Grant No. 161017), the Fundamental Research Funds for the Central Universities (Grant No. 22221818014), and the 111 Project (B18022).

语种：英文

外文关键词：Indicators (chemical) - Textile industry - Liquid crystals - Biochemistry - Polyamides - Synthetic biology - Chemical contamination - Plants (botany) - Rayon - Metabolic engineering

摘要：Medium-chain dicarboxylic acids (MDCAs) are widely used in the production of nylon materials such as nylon 5,6 and nylon 6,6, and among which, succinic, glutaric, adipic, pimelic, suberic, azelaic and sebacic acids are particularly important for that purpose, and also serve as platform chemicals for chemical, food, textile, pesticide, pharmaceutical and liquid crystal industries. Although most of these MDCAs are chemically synthesized, their biosynthesis has become more important due to the fast growth of biotechnology. Compared with chemical production and plant extraction, microbial-based production is more environmentally friendly and sustainable. In this review article, we critically comment existing methods for producing MDCAs and their biosynthesis, emphasizing metabolic engineering and synthetic biology strategies, which could help overcome barriers ahead and facilitate efficient bio-based production of MDCAs in the future.