文献类型：期刊文献

英文题名：Lithium doped silica nanospheres/poly(dopamine) composite coating on polyetheretherketone to stimulate cell responses, improve bone formation and osseointegration

作者：Zhang, Jue[1];Cai, Liang[1];Wang, Tinglan[1];Tang, Songchao[1];Li, Quan[2];Tang, Tingting[3];Wei, Shicheng[4];Qian, Jun[1];Wei, Jie[1];Su, Jiacan[2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed Trauma, Shanghai, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants,Sch Med, Shanghai, Peoples R China;[4]Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Lab Interdisciplinary Studies, Beijing, Peoples R China

年份：2018

卷号：14

期号：3

起止页码：965

外文期刊名：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

收录：;EI(收录号：20181004854456);WOS:【SCI-EXPANDED(收录号:WOS:000429528900030)】；

基金：The grants were from the National Key Research and Development Program (2016YFC1102100), the National Natural Science Foundation of China (81771990, 51502340 and 81572194), the Major International Joint Research Project between China and Korea (81461148033) and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implants.

语种：英文

外文关键词：Lithium doping silica nanospheres; Poly(dopamine); Composite coating; Polyetheretherketone; Osseointegration

摘要：Osseointegration is crucial for early fixation as well as long-term success of orthopedic implants. Bioactive composite containing lithium doping silica nanospheres (LSNs) and poly(dopamine) (PDA) were coated on polyetheretherketone (PK) surface (LPPK), and effects of the LSNs/PDA composite (LPC) coating on the biological properties of LPPK were assessed both in vitro and in vivo. Results showed that LPPK with improved bioactivity remarkably promoted apatite mineralization in simulated body fluid (SBF) compared with PDA coated on PK (PPK) and PK. Moreover, the LPPK remarkably stimulated rat bone marrow stromal cells (rBMSCs) responses compared with PPK and PK. Furthermore, the LPPK significantly promoted bone tissues responses in vivo compared with PPK and PK. It could be suggested that the improvements of cells and bone tissues responses were attributed to the surface characteristics of the bioactive LPC coating on LPPK. The LPPK would be a great candidate for orthopedic and dental applications. (c) 2018 Elsevier Inc. All rights reserved.