文献类型：期刊文献

英文题名：Oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles

作者：Jiang, Qiangqiang[1];Qi, Xinghui[1];Zhang, Chenyang[1];Ji, Xuan[1];Li, Jin[2];Liu, Renhua[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]China Catalyst Holding Co Ltd, Jingjiu Rd 3,Chem Pk, Dalian 116699, Peoples R China

年份：2018

卷号：5

期号：3

起止页码：386

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806137458);WOS:【SCI-EXPANDED(收录号:WOS:000424012100009)，CCR-EXPANDED(收录号:WOS:000424012100009)】；

基金：This work was financially supported by the National Natural Science Foundation of China (grants 21072055).

语种：英文

外文关键词：Catalysis - Oxidants - Cyclization - Hydrogen

摘要：An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed through palladium(0) catalyzed dehydrogenative cyclization of N-arylidenearoylhydrazides. By using this method, a wide range of functionalized and potentially biologically relevant 1,3,4-oxadiazole-containing compounds have been accessed in moderate to high isolated yields. The dehydrogenative cyclization process is characterized by the nonuse of any sacrificing hydrogen acceptors or oxidants and hydrogen gas as the only by-product, and therefore circumvents the recurring problems of over-oxidation and the compatibility with easily oxidizable functionalities in oxidation protocols.