文献类型：期刊文献

英文题名：Direct three-dimensional printing of a highly customized freestanding hyperelastic bioscaffold for complex craniomaxillofacial reconstruction

作者：Ma, Yifan[1,2,7];Zhang, Changru[1,2,3,4];Wang, Yanxiang[1,2,3,4];Zhang, Lanzhu[6];Zhang, Jingjing[7];Shi, Jun[5];Si, Jiawen[5];Yuan, Yuan[1,2,3,4];Liu, Changsheng[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomat, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[5]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Oral & Craniomaxillofacial Surg,Coll Stomato, Natl Clin Res Ctr Oral Dis,Sch Med,Shanghai Key L, Shanghai 200011, Peoples R China;[6]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[7]Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43210 USA

年份：2021

卷号：411

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20210509855409);WOS:【SCI-EXPANDED(收录号:WOS:000624638900001)】；

基金：The authors wish to express their gratitude to the financial supports from the National Natural Science Foundation of China (Nos. 31771040, 31971264, 81600827), National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) and Leading talents in Shanghai in 2017.

语种：英文

外文关键词：Free-standing 3D printing; Bioscaffold; Urethane-based PEGylated poly(glycerol; sebacate); High customization; Craniomaxillofacial reconstruction

摘要：Due to the anatomical and functional complexities, craniomaxillofacial defects are considered as one of the most intractable orthopedic challenges worldwide. Despite substantial attention given to the development of tissue engineering biomaterials, poor customization, function, and clinical application of current artificially fabricated bone grafts remain, particularly undesirable mechanical properties and bioactivity to reproducibly regenerate new bone, and lack of surgical and clinical significance. To address these drawbacks, a freestanding 3D-printing bioscaffold with the biomimetic formulation and highly customized performance was developed. With the incorporation of urethane-based PEGylated poly(glycerol sebacate) (PEGSU) in ceramic bioinks, the resultant scaffolds can be printed with rapid self-prototyping in low temperature, exhibiting enhanced mechanical strength and hyperelasticity, and supporting cell proliferation and osteogenic differentiation. As indicated by in vivo experiments, the printed grid scaffolds can promote new bone formation in critical-sized cranial defects and thus providing instant protection for sensitive tissues after craniectomy. Furthermore, anatomically scaled craniomaxillofacial bone structures can be printed with high fidelity, and finite element analysis confirmed their routine functionalities after implantation. With these advantages, this self-standing 3D printed biomaterial shows great prospect of clinical application in craniomaxillofacial bone regeneration and provides new horizons for other complex reconstructions.