文献类型：期刊文献

英文题名：Multifunctional magnetic nanoparticles for simultaneous cancer near-infrared imaging and targeting photodynamic therapy

作者：Zhao, Xueling[1];Chen, Zongyan[1];Zhao, Hongli[1];Zhang, Denghao[1];Tao, Liang[1];Lan, Minbo[1,2]

机构：[1]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：4

期号：107

起止页码：62153

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20144800270109);WOS:【SCI-EXPANDED(收录号:WOS:000345660300017)】；

基金：This research was financially supported by the Science and Technology Commission of Shanghai Municipality (STCSM, contract no. 13ZR1412000 and 12nm0501100).

语种：英文

外文关键词：Diseases - Cancer cells - Targeted drug delivery - Fluorescence imaging - Silica - Photosensitizers - Aromatic compounds - Infrared devices - Magnetite - Nanomagnetics - Controlled drug delivery - Thermography (imaging) - Nanoparticles

摘要：Cancer theranostics, the ability to simultaneously diagnose and treat cancer, has become one of the major driving forces in nanobiotechnology. In the present work, a multifunctional system, methylene blue-incorporated folate-functionalized Fe3O4/mesoporous silica core-shell magnetic nanoparticles (MNPs), for simultaneous near-infrared (NIR) fluorescence imaging and targeting photodynamic therapy (PDT) has been developed. The core Fe3O4 MNPs offers the function of magnetically guided drug delivery, the mesoporous silica shell acts as an efficient drug loaded carrier, the photosensitizer methylene blue (MB) exhibits excellent NIR fluorescence imaging and PDT efficiency, and the folic acid (FA) can effectively enhance the delivery of MB to the targeting cancer cells, which overexpress the folate receptor. The results indicated that the multifunctional system could effectively be used in NIR fluorescence imaging. Moreover, it exhibited a synergistic effect of magnetic targeted PDT of cancer under NIR laser irradiation. Thus, the multifunctional system is promising for simultaneous cancer diagnosis and therapy.