文献类型：期刊文献

英文题名：Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

作者：Sun, Ke[1];Ding, Zhe[2,3];Jia, Xiaoying[3];Cheng, Haonan;Li, Yingwen[2,3];Wu, Yan[4];Li, Zhuoyu[1];Huang, Xiaohua[1];Pu, Fangxu[1];Li, Entao[5];Wang, Guiyou[1];Wang, Wei[3];Ding, Yun[1];Wong, Gary[2];Chiu, Sandra[5,6];Lan, Jiaming[2];Hu, Aiguo[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, CAS Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China;[3]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[4]Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China;[5]Univ Sci & Technol China, Div Life Sci & Med, Hefei 230027, Anhui, Peoples R China;[6]Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Clin Lab, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China

年份：2023

外文期刊名：CCS CHEMISTRY

收录：WOS:【ESCI(收录号:WOS:000991565700001)】；

基金：Funding Information This research was made possible as a result of a generous grant from the National Natural Science Foundation of China (grant no. 21871080) , the Eastern Scholar Profes-sorship (for A.H.) , and the Natural Science Foundation of Shanghai (grant no. 20ZR1463900) (for J.L.) .

语种：英文

外文关键词：enediyne; broad spectrum antiviral; pro-tein disintegration; coronavirus; polyanions

摘要：The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed millions of lives and caused innumerable economic losses worldwide. Unfortunately, state-of-the-art treatments still lag behind the continual emergence of new variants. Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural evolution. Here, we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne (EDY) molecules. The core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus, while the hyperanion groups ensure negligible cytotoxicity of the molecules. The EDYs exhibit antiviral activity down to nanomolar concentrations, and the selectivity index of up to 20,000 against four kinds of human coronavirus, including the SARS-CoV-2 Omicron variant, suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future "disease X."