文献类型：期刊文献

英文题名：Protective effects of Lactobacillus plantarum strain P1 against toxicity of the environmental oestrogen di-n-butyl phthalate in rats

作者：Shi, X.[1];Hu, C.[1];Cai, S.[1];Tao, X.[2];Zhou, Y.[1,3];Smidt, H.[3];Ye, B.[2]

机构：[1]East China Univ Sci & Technol, Sch Bioengn, Dept Food Sci & Technol, Meilong RD 130, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Lab Biosyst & Microanal, State Key Lab Bioreactor Engn, Meilong RD 130, Shanghai 200237, Peoples R China;[3]Wageningen Univ & Res, Lab Microbiol, Stippeneng 4, NL-6708 WE Wageningen, Netherlands

年份：2020

卷号：11

期号：8

起止页码：803

外文期刊名：BENEFICIAL MICROBES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000596624800007)】；

基金：We thank Prof. Bo Chen from Fudan University for valuable comments on the experiment design. This research was supported by the Shanghai Municipal Science and Technology Commission Project (18JC1410802) and Fundamental Research Funds for the Central Universities (222201714051). The authors gratefully acknowledge financial support from China Scholarship Council (201806745020).

语种：英文

外文关键词：Lactobacillus plantarum; phthalate; adsorption; sexual development

摘要：Phthalates are contaminants widely distributed in the food-chain, and they are considered as important environmental oestrogens in our lives. In the present study, eight strains of lactic acid bacteria were isolated for their ability to adsorb di-n-butyl-phthalate (DBP), and one of the strains, Lactobacillus plantarum strain P1, was selected for more detailed analyses of its phthalate adsorption capacity in vitro. This study also evaluated the in vivo protective effects of strain P1 against DBP toxicity in rats. Sixteen rats were divided into four groups, and animals received by oral gavage every other day for a period of one month saline with or without strain P1 at 2x10(11) cfu/kg followed by maize oil with or without DBP (50 mg/kg). Strain P1 could adsorb more DBP than saline alone, and the concentration of mono-n-butyl phthalate in urine was decreased in animals receiving P1. Furthermore, oestrogenic effects of the different treatments were assessed through counting of sperm and observation of testis, and strain P1 could protect the sexual organs of male rats. Our results suggested that P1 is effective against phthalate toxicity due to its ability to adsorb DBP in vivo and could be considered as a new dietary therapeutic strategy against environmental phtalate toxicity.