文献类型：期刊文献

英文题名：A pH/H2O2 dual triggered nanoplatform for enhanced photodynamic antibacterial efficiency

作者：Zhao, Ying[1];Zhu, Yucheng[1];Yang, Guoliang[1];Xia, Lei[1];Yu, Fan[1];Chen, Chao[2];Zhang, Liangshun[1];Cao, Hongliang[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, Biomed Nanotechnol Ctr, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：9

期号：25

起止页码：5076

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20212710586061);WOS:【SCI-EXPANDED(收录号:WOS:000660903300001)】；

基金：This work was financially supported by the Natural Science Foundation of Shanghai (18ZR1408300).

语种：英文

外文关键词：Bacteria - Efficiency - Irradiation - Photodynamic therapy - Synthesis (chemical) - Controlled drug delivery - Biofilms - Targeted drug delivery - Block copolymers

摘要：Bacterial infection and biofilms cause non-healing chronic wounds and threaten human health. Although antibiotics still play an irreplaceable role to treat infectious diseases in clinics, increasing attention has been paid to the problem of multidrug resistance (MDR). As a novel strategy to deal with bacterial infection, photodynamic antimicrobial therapy (PDAT) has shown promising potential to reduce bacterial infection, and stimuli-responsive nanomaterials have been shown to enhance the antibacterial efficiency and postpone the emergence of drug-resistant bacteria. In this work, we developed a bacterial microenvironment-responsive nanoplatform to eliminate bacteria and bacterial biofilms under 650 nm laser irradiation. Reversible addition-fragmentation chain transfer (RAFT) polymerization was applied to synthesize an H2O2 responsive block copolymer of POEGMA-b-PBMA, and the antibacterial drug of porphyrin TAPP was loaded to form nanoparticles (PT) by a co-assembled approach. At the infection area with overexpressed peroxide, nanoparticles were disintegrated due to the cleaved boronic ester leading to the release of TAPP. Furthermore, the released TAPP became protonated in the acidic infection area (pH = 5.5) and then enhanced its photodynamic antibacterial efficacy by producing higher singlet oxygen (O-1(2)) levels under light irradiation. Both in vitro and in vivo antimicrobial and biofilm elimination experiments demonstrated that the responsive nanoplatform combined with PDAT has tremendous potential for the treatment of infections.