文献类型：期刊文献

英文题名：Rapid construction of cyclopenta[b]naphthalene frameworks from propargylic alcohol tethered methylenecyclopropanes

作者：Wei, Hao-Zhao[1,2];Li, Quan-Zhe[1,2];Wei, Yin[3];Shi, Min[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Ling Ling Lu, Shanghai 200032, Peoples R China

年份：2020

卷号：18

期号：37

起止页码：7396

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20204109336141);WOS:【SCI-EXPANDED(收录号:WOS:000577016000016)，CCR-EXPANDED(收录号:WOS:000577016000016)】；

基金：We are grateful for the financial support from the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000), the National Natural Science Foundation of China (21372250, 21121062, 21302203, 20732008, 21772037, 21772226, 21861132014 and 91956115) and the Fundamental Research Funds for the Central Universities (222201717003).

语种：英文

外文关键词：Cyclization - Naphthalene - Alcohols - Chlorine compounds

摘要：We have developed a new synthetic methodology for the rapid construction of cyclopenta[b]naphthalene frameworks from the reaction of propargylic alcohol tethered methylenecyclopropanes with mesyl chloride in the presence of triethylamine through cascade cyclization. The reaction can be performed under mild conditions without the use of transition metals, affording the target products in moderate to good yields, and this cyclization reaction process can be scaled up to a gram-scale synthesis.