文献类型：期刊文献

英文题名：Organic/inorganic hybrid star-shaped block copolymers of poly(l-lactide) and poly(N-isopropylacrylamide) with a polyhedral oligomeric silsesquioxane core: Synthesis and self-assembly

作者：Zhang, Weian[1]; Wang, Shaohua[1]; Li, Xiaohui[1]; Yuan, Jiayin[2]; Wang, Shaolei[1]

机构：[1] Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; [2] Makromolekulare Chemie II, Universit?t Bayreuth, D-95440 Bayreuth, Germany

年份：2012

卷号：48

期号：4

起止页码：720

外文期刊名：European Polymer Journal

收录：EI(收录号：20121214885486)

语种：英文

外文关键词：Biological materials - Atomic force microscopy - Dynamic light scattering - Free radical polymerization - organic-inorganic materials - Self assembly - Solutions - Stars - Amides - Ring opening polymerization - High resolution transmission electron microscopy - Acrylic monomers - Hydrogels - Oligomers

摘要：The star-shaped organic/inorganic hybrid poly(l-lactide) (PLLA) based on polyhedral oligomeric silsesquioxane (POSS) was prepared using octa(3-hydroxypropyl) polyhedral oligomeric silsesquioxane as initiator via ring-opening polymerization (ROP) of l-lactide (LLA). The molecular weight of POSS-containing star-shaped hybrid PLLA (POSSPLLA) can be well controlled by the feed ratio of LLA to initiator. The POSSPLLA was further functionalized into the macromolecular reversible addition-fragmentation transfer (RAFT) agent for the polymerization of N-isopropylacrylamide (NIPAM), leading to the POSS-containing star-shaped organic/inorganic hybrid amphiphilic block copolymers, poly(l-lactide)-block-poly(N-isopropylacrylamide) (POSS(PLLA-b-PNIPAM)). The self-assembly behavior of POSS(PLLA-b-PNIPAM) block copolymers in aqueous solution was investigated by dynamic light scattering (DLS), transmission electron microscopy (TEM) and atomic force microscopy (AFM). DLS showed the PNIPAM block in the aggregates is temperature-responsive and its phase-transition is reversible. TEM proved that the star-shaped POSS(PLLA-b-PNIPAM) amphiphilic block copolymers can self-assemble into the vesicles in aqueous solution. The vesicular wall and coronas are composed of the hydrophobic POSS core and PLLA, and hydrophilic PNIPAM blocks, respectively. Therefore, POSSPLLA and POSS(PLLA-b-PNIPAM) block copolymers, as a class of novel organic-inorganic hybrid materials with the advantageous properties, can be potentially used in biological and medical fields. ? 2012 Elsevier Ltd. All rights reserved.